MicroRNAs and fibrosis
نویسندگان
چکیده
منابع مشابه
MicroRNAs in renal fibrosis
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that regulate most of important cellular processes by inhibiting gene expression through the post-transcriptional repression of their target mRNAs. In kidneys, miRNAs have been associated in renal development, homeostasis, and physiological functions. Results from clinical and experimental animal studies demonstrate that miRNAs play essent...
متن کاملRole of MicroRNAs in Fibrosis
Fibrosis is the leading cause of organ dysfunction in diseases such as systemic sclerosis, liver cirrhosis, cardiac fibrosis, progressive kidney disease, and idiopathic pulmonary fibrosis. The hallmark of fibrosis is tissue remodeling with excess deposition of extracellular matrix components, predominantly collagens. Different cell types, cytokines, growth factors, and enzymes interact in compl...
متن کاملMicroRNAs in fibrosis: opportunities and challenges
MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts. They are master regulators of gene expression. Fibrosis is an important cause of morbidity and mortality in the world, and there are currently n...
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Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. There are two main factors facilitating the formation and persistence of AF: enhanced automaticity in some rapidly depolarizing foci and abnormal conduction substrates [1]. Fractionated or fragmented electrograms during AF were initially reported by Konings et al. [2] Then, other authors d...
متن کاملOverview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The select...
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ژورنال
عنوان ژورنال: Current Opinion in Nephrology and Hypertension
سال: 2012
ISSN: 1062-4821
DOI: 10.1097/mnh.0b013e328354e559